Neurotensin Peptide
- Cat.Number : AS-22985
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This peptide is bovine neurotensin, which contains an N-terminal pyroglutamic acid. Neurotensin is a 13 amino acid neuropeptide first isolated from bovine hypothalamus. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract, where it inducessmooth muscle contraction. In the CNS, neurotensin has a dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It also shows potent hypothermic and analgesic effects in the brain. Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases.
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References
Neurotensin: a physiological regulator of exocrine pancreatic secretion?
Italian J. Gastroenterol . 1992 Jul 01 ; 24(6) 347 | DOI : PMID: 1515662
- L. Gullo
- et al
Does neurotensin mediate the effects of antipsychotic drugs?
Biol. Psychiatr. . 1999 Aug 01 ; 46(3) 340 | DOI : https://doi.org/10.1016/S0006-3223(99)00070-0
- B. Kinkead
- et al