[Pyr1]-Apelin-13 - 1 mg
- Cat.Number : AS-60833
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[125I]-(Pyr1)Apelin-13 binds with high affinity and selectivity to human cardiac tissue. Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77). Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue.
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Citations
Increased bone mass in mice lacking the adipokine apelin.
Endocrinol . 2013 Apr 12 ; 154(6) 2069 | DOI : 10.1210/en.2012-2034
- L. Wattanachanya
References
[125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
Brit. J. Pharma. . 2001 Mar 01 ; 132(6) 1255 | DOI : https://doi.org/10.1038/sj.bjp.0703939
- SD Katugampola
- et al
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
Biochem Biophys Res Commun . 1998 Oct 20 ; 251(2) 471 | DOI : https://doi.org/10.1006/bbrc.1998.9489
- K. Tatemoto
- et al