[Pyr3]-beta-Amyloid (3-40)
- Cat.Number : AS-29906-01
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A hallmark of Alzheimer's disease (AD) is the presence of beta-Amyloid in plaques in the brains of patients. N-terminally truncated pyroglutamate-modified beta-Amyloid forms such as Aß(3-40) and Aß (11- 40) have been described as major compounds in the senile plaques. Pyro-Glu modified beta-Amyloid forms are more resistant to degradation, show higher toxicity and have increased aggregation propensity compared to non-modified beta-Amyloid.
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References
Aβ peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture
J Neurosci Res . 2000 Aug 15 ; 61(4) 449 | DOI : https://doi.org/10.1002/1097-4547(20000815)61:4<449::AID-JNR12>3.0.CO;2-N
- SS. Mok
- et al
Presenilin-1 mutations in Alzheimer's disease
Neurobiol Nature . 2000 Jun 01 ; 405 531 | DOI : https://doi.org/10.1038/35014735
- C. Russo
- et al