Renin FRET Substrate (5-FAM/QXL® 520), rat - 0.1 mg
- Cat.Number : AS-62334-01
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This renin FRET peptide is a specific substrate for rat renin. Aspartyl protease cleaves angiotensinogen to yield angiotensin I, which is further converted to angiotensin II. The renin-angiotensin system is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function. It governs body fluid and electrolyte balance, as well as arterial pressure. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. This renin peptide substrate may be used for screening renin inhibitors. In the FRET peptide, the fluorescence of 5-FAM is quenched by QXL® 520. Upon cleavage into two separate fragments by rat renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm. The SensoLyte® 520 Renin Assay Kit (cat # 72040) contains the human renin FRET substrate.
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Citations
Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice
J Renin Angiotensin Aldosterone Syst . 2016 May 23 ; 17(2) 1470320315625700 | DOI : 10.1177/1470320315625704
- K. Kidokoro
Modulation of the angiogenic phenotype of normal Systemic Sclerosis endothelial cells by gain-loss of function of PTX3 MMP12
Arthritis Rheum. . 2010 Aug 01 ; 62(8) 2488 | DOI : 10.1002/art.27522
- F. Margheri
Multiphoton imaging of renal regulatory mechanisms
Physiology (Bethesda). . 2009 Apr 01 ; 24 88 | DOI : 10.1152/physiol.00001.2009
- J. Peti-Peterdi
Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure
Am J Physiol Regul Integr Comp Physiol. . 2008 Jun 25 ; 295(2) R371 | DOI : 10.1152/ajpregu.00468.2007
- F. Hanner