IMG-EN-AS-29898-01.jpg
Peptides

RGD-4C - 5 mg

$2,189.00
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  • Cat.Number : AS-29898
  • Availability :
    In production

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This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells.

Specifications

Chemistry
Sequence one letter code
  • ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)
Sequence three letter code
  • H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-OH (Disulfide bridge: 2-10 and 4-8)
Molecular Formula
  • C42H64N14O16S4
Molecular Mass/ Weight
  • 1145.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • synthetic

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Citations

Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes

Mol Cancer Ther.  . 2009 May 05 ; 8(5) 1312 | DOI : 10.1158/1535-7163.MCT-08-1105

  • K. Dane

Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein.

Mol Cancer Ther. . 2008 May 01 ; 7(5) 1044 | DOI : 10.1158/1535-7163.MCT-07-2084

  • H. Wang

Adenoviral‐encoded antigens are presented efficiently by a subset of dendritic cells expressing high levels of αvβ3 integrins

J Leukocyte Bio . 2006 Mar 30 ; 79(6) 1271 | DOI : https://doi.org/10.1189/jlb.1105694

  • A. Harui

Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries.

Cancer Res. . 2006 Jan 01 ; 66(1) 34 | DOI : 10.1158/0008-5472.CAN-05-2748

  • MG. Kolonin

Targeting Tumor Angiogenesis: Comparison of Peptide and Polymer-Peptide Conjugates

J Nucl Med . 2005 Sep 01 ; 46(9) 1552 | DOI : PMID: 16157540

  • BR. Line

In vitro assessment of blood compatibility: Residual and dynamic markers of cellular activation

J Biomater Appl. . 2011 Dec 29 ; 27(8) 925 | DOI : 10.1177/0885328211428525

  • G. Johnson

References

Anti-cancer activity of targeted pro-apoptotic peptides

Nature Med . 1999 Sep 01 ; 5 1032

  • H. Ellerby
  • et al

Coupling Tumor Necrosis Factor-α with αv Integrin Ligands Improves Its Antineoplastic Activity

Cancer Res. . 2004 Jan 15 ; 64 565 | DOI : 10.1158/0008-5472.CAN-03-1753

  • F. Curnis
  • et al

In Vitro and in Vivo Evaluation of a Technetium-99m-Labeled Cyclic RGD Peptide as a Specific Marker of αVβ3 Integrin for Tumor Imaging

Bioconjug Chem . 2002 Apr 20 ; 13(3) 561 | DOI : https://doi.org/10.1021/bc0155566

  • Z. Su
  • et al