Peptides

S3 Fragment, ADF/cofilin, LIMK1 substrate - 1 mg

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  • Cat.Number : AS-62637
  • Availability :
    In production

Quantity

This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.

Specifications

Chemistry
Sequence one letter code
  • MASGVMVSDDVVKVFN
Sequence three letter code
  • H-Met-Ala-Ser-Gly-Val-Met-Val-Ser-Asp-Asp-Val-Val-Lys-Val-Phe-Asn-OH
Molecular Formula
  • C73H120N18O24S2
Molecular Mass/ Weight
  • 1698.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Xenopus

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References

BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin

J Cell Biol . 2007 Jul 02 ; 178(1) 107 | DOI : https://doi.org/10.1083/jcb.200703055

  • Z. Wen
  • et al