SensoLyte® 490 MMP-12 Assay Kit Fluorimetric - 1 kit
- Cat.Number : AS-71137
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Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is implicated in the pathology of many diseases such as emphysema, aortic lesions and cancer. It has recently been shown to play a role in the pathogenesis of rheumatoid arthritis. The SensoLyte® 490 MMP-12 Assay Kit is a complete assay system designed to continuously analyze MMP-12 activity or to screen for MMP-12 inhibitors by using a fluorogenic MMP-12 substrate.
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Citations
Expression of matrix metalloproteinase-12 in aortic dissection
BMC Cardiovasc Disord . 2013 May 03 ; 13 34 | DOI : 10.1186/1471-2261-13-34
- Y. Song
Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity
Free Radic Res. . 2012 Jun 08 ; 46(9) 1123 | DOI : 10.3109/10715762.2012.692786
- K.H. Chan
Inflammatory signatures for eosinophilic versus neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints
Am J Physiol Lung Cell Mol Physiol. . 2011 Feb 18 ; 300(5) L679 | DOI : 10.1152/ajplung.00202.2010
- P. Bogaert
Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition
Cancer Res . 2009 Aug 25 ; 69(18) 7252 | DOI : 10.1158/0008-5472.CAN-09-0577
- P. Qu
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice
Mol Genet Metab . 2008 Mar 13 ; 94(3) 298 | DOI : 10.1016/j.ymgme.2008.03.018
- X. Ma
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice
Am J Physiol Lung Cell Mol Physiol. . 2008 Mar 07 ; 294(6) L1035 | DOI : 10.1152/ajplung.00397.2007
- R. Summer
Elevated MMP-12 protein levels in induced sputum from patients with COPD
Thorax . 2005 Nov 24 ; 61(3) 196 | DOI : 10.1136/thx.2005.042432
- I.K. Demedts