SensoLyte® AFC Plasmin Activity Assay Kit Fluorimetric - 1 kit
- Cat.Number : AS-72124
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Plasmin belongs to the family of serine proteases. It plays a key role in fibrinolysis by dissolving fibrin in blood clots. Besides fibrinolysis, plasmin is also involved in such physiological and pathological processes as wound healing, liver repair, and the maintenance of liver homeostasis.
The SensoLyte® AFC Plasmin Activity Assay Kit provides a convenient assay for high throughput screening of plasmin inhibitors and inducers or for continuous assay of plasmin activity. The assay utilizes a fluorogenic peptide, which upon enzyme cleavage releases the AFC (7-amido-4-trifluoromethylcoumarin) fluorophore. The fluorescent signal can be measured at Ex/ Em =380 nm/500 nm. This assay can detect picogram level of plasmin activity.
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Citations
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Intravenous and oral administrations of DD2 [7-Amino-2-(sulfanylmethyl)heptanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrombosis
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uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
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Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria
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- K. Tudpor
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
J Biol Chem . 2015 Nov 30 ; 291(6) 2874 | DOI : 10.1074/jbc.M115.704841
- S. Ambadapadi
Nano-zymography Using Laser-Scanning Confocal Microscopy Unmasks Proteolytic Activity of Cell-Derived Microparticles
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- A. Briens
- et al