Fibrinogen gamma-Chain (377-395) - 1 mg
- Cat.Number : AS-62128
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Activation of the coagulation cascade converts fibrinogen to fibrin, through binding of an epitope in the fibrinogen γ chain (γ377–395) to CD11b/CD18 integrin (Mac-1). In the central nervous system, fibrinogen has been associated to demyelination and microglial activation, while this peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Since blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma-fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.
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References
The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
J. Exp. Med. . 2007 Mar 05 ; 204(3) 571 | DOI : https://doi.org/10.1084/jem.20061931
- R. Adams
- et al