Peptides

Fibrinogen gamma-Chain (377-395) - 1 mg

$118.00
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  • Cat.Number : AS-62128
  • Availability :
    In stock

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Activation of the coagulation cascade converts fibrinogen to fibrin, through binding of an epitope in the fibrinogen ? chain (?377–395) to CD11b/CD18 integrin (Mac-1). In the central nervous system, fibrinogen has been associated to demyelination and microglial activation, while this peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Since blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma-fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.

Specifications

Chemistry
Sequence one letter code
  • YSMKETTMKIIPFNRLSIG
Sequence three letter code
  • H-Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly-OH
Molecular Formula
  • C100H165N25O28S2
Molecular Mass/ Weight
  • 2229.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse

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