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Assay-kits

SensoLyte® Anti-PLP (139-151) IgG Quantitative ELISA Kit (mouse) Colorimetric - 1 kit

$582.00
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  • Cat.Number : AS-55524
  • Availability :
    In production
  • Shipping conditions : Ice fees will apply

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Proteolipid protein (PLP) is the most abundant protein in the central nervous system (CNS) myelin sheath and is highly conserved among species. PLP has a 50% hydrophobic amino acids content and a molecular weight of 30 kDa. Mouse PLP (139-151) is able to induce autoantibody production and relapsing-remitting neurological disease causing extensive plaque-like demyelination. Autoantibody response to mouse PLP (139-151) has been observed in induced experimental autoimmune encephalomyelitis (EAE) in SJL, F1, and SWR mice strains. However, the exact pathological role
and action of anti-mouse PLP (139-151) autoantibody is not well understood.
The SensoLyte® Anti-PLP (139-151) IgG Quantitative ELISA Kit (mouse) provides a convenient and quantitative assay for anti-PLP (139-151) autoantibody in mouse. This kit is useful to researchers who wants to determine the amount of anti-PLP (139-151) antibody present in biological samples, and can help provide information on the role it plays in the development and treatment of EAE, an animal model for MS pathogenesis.

Specifications

Packaging
Kits components
  • Component A: PLP (139-151) coated and BSA blocked 8-well strips: 12 x 8 strips Component B: Mouse anti-PLP (139-151) IgG Standard: 100 µl (20 µg/ml) Component C: 1X Sample Dilution Buffer: 30 ml Component D: 10X Wash Buffer: 50 ml Component E: TMB color substrate solution: 10 ml Component F: Stop Solution: 10 ml Component G: Secondary antibody, Goat anti-Mouse IgG-HRP: 30 µl
Chemistry
UniProt number
  • P60202
Storage & stability
Storage Conditions
  • Store all other components at 4°C for up to 6 months. Store component B at -20°C in small aliquots. Protect components E and G from light.
Activity
Application
Biomarker Target
Detection Method
Detection Limit
  • 100 pg
Specificity
  • mouse
Research Area
Sub-category Research Area
Usage
  • Research use

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