Somatostatin 14, human, rat, mouse, pig, chicken, frog
- Cat.Number : AS-24277
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Somatostatin [SST, GHIH (growth hormone-inhibiting hormone) or SRIF (somatotropin release-inhibiting factor)] is a cyclic peptide hormone existing as two isoforms and produced in the pancreas islet, GI tract and the central nervous system. Tetradecapeptide Somatostatin-14 (SRIF-14, the originally identified somatostatin) and the 28-amino acid Somatostatin-28 (SRIF-28) have similar biological activities but differ in their potency. Somatostatins regulate the endocrine system: they inhibit the release of growth hormone in contrast to Growth Hormone Factor (GRF), which stimulates the release of growth hormone. They also inhibit the release of prolactin and thyrotropin, peptide hormones from the pituitary gland and glucagon and insulin from the pancreas. They control the secretion of gut hormones and function as neurotransmitters.
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Citations
The use of acetone as a substitute for acetonitrile in analysis of peptides by liquid chromatography/electrospray ionization mass spectrometry.
Rapid Comm Mass Spectrom . 2010 Jan 01 ; 24(1) 6 | DOI : 10.1002/rcm.4352
- T. Keppel
Gonadotropin releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH) in the songbird hippocampus: regional and sex differences in adult zebra finches.
Peptides. . 2013 Mar 29 ; 46 64 | DOI : 10.1016/j.peptides.2013.05.007
- N. McGuire
Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii
J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200
- AJ. O'Donoghue
A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors
J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531
- X. Zhao
References
Duodenal Somatostatinoma Associated with Diabetic Ketoacidosis Presumably Caused by Somatostatin-28 Hypersecretion
J Clin Endocrinol Metab . 2005 Nov 01 ; 90(11) 6310 | DOI : https://doi.org/10.1210/jc.2004-1904
- D. Kim
- et al
Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain
PNAS . 1992 Nov 01 ; 89(21) 10267 | DOI : https://doi.org/10.1073/pnas.89.21.10267
- W. Meyerhof
- et al