Protein

Tau (Tau-441), human recombinant, GST tagged

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  • Cat.Number : AS-55557-50
  • Availability :
    In stock
  • Shipping conditions : Ice fees will apply

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Microtubule associated protein (Tau) is found predominantly in the central neural system and its major function is to promote assembly and to stabilize neuronal microtubules. Six isoforms of Tau were identified in humans that are differentiated by the exclusion or inclusion of exons 2, 3, and 10. Tau-441 is the longest of Tau isoforms that consists of 441 amino acids with molecular mass of 45.8 kDa.
Under physiological conditions Tau can undergo abnormal phosphorylation, truncation, or other modifications that result in the protein detachment from microtubules. These modified Tau molecules can self-associate and form different types of aggregates including neurofibrillary tangles (NFTs) found in brains of patients with neurodegenerative diseases such as Alzheimer’s disease.

The sequence (Accession # AAC04279.1) corresponding to the full length human Tau-441 (2N4R isoform) protein along with GST tag was expressed in E. coli. Recombinant Tau-441 protein was purified from bacterial lysate using proprietary method. MM = 71,8 kDa

Specifications

Chemistry
UniProt number
  • P10636
Molecular Mass/ Weight
  • 71.8 kDa (higher apparent mass in SDS-PAGE)
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • none (lyophilized)
Purification Method
  • Purified
Purity
  • ≥90% by SDS-PAGE
Storage & stability
Form
  • Lyophilized
Storage Buffer
  • The purified Tau-441 is supplied as lyophilized powder salt free.
Storage Conditions
  • Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for long-term storage. Avoid repeated freeze-thaw cycles
Activity
Application
Biomarker Target
Specificity
  • full length human Tau-441 (2N4R isoform) protein
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human

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