Peptides

Temporin A, amide - 1 mg

$110.00
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  • Cat.Number : AS-64831
  • Availability :
    In stock

Quantity

Temporin A is a highly hydrophobic antimicrobial peptide amide derived from the frog Rana temporaria. This antimicrobial peptide exerts its effect by inducing the migration of human monocytes, macrophages, and neutrophils, thus modulating the permeability of the microbial membrane to allow passage of various-sized molecules and exhibiting activity against gram-positive bacteria, particularly antibiotic-resistant gram-positive cocci. Temporin A activity is enhanced when used in combination with other antimicrobial agents.

Specifications

Chemistry
Sequence one letter code
  • FLPLIGRVLSGIL-NH2
Sequence three letter code
  • H-Phe-Leu-Pro-Leu-Ile-Gly-Arg-Val-Leu-Ser-Gly-Ile-Leu-NH2
Molecular Formula
  • C68H117N17O14
Molecular Mass/ Weight
  • 1396.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • frog

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Citations

Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis.

Anal Chem . 2012 Apr 16 ; 84(9) 4237 | DOI : 10.1021/ac300540r

  • Y. Fukuyama

References

A Synergism between Temporins toward Gram-negative Bacteria Overcomes Resistance Imposed by the Lipopolysaccharide Protective Layer

J Biol Chem . 2006 Sep 01 ; 281(39) 28565 | DOI : https://doi.org/10.1074/jbc.M606031200

  • Y. Rosenfeld
  • et al

In vitro activity and killing effect of temporin A on nosocomial isolates of Enterococcus faecalis and interactions with clinically used antibiotics

J Antimicrob Chemother . 2005 Feb 01 ; 55(2) 272 | DOI : https://doi.org/10.1093/jac/dkh545

  • A. Giacometti
  • et al

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family

Pharmacol Rev . 2009 Jun 01 ; 61(2) 119 | DOI : 10.1124/pr.109.001578

  • R. Ye
  • et al