Thrombospondin (TSP-1) Inhibitor, LSKL - 1 mg
- Cat.Number : AS-60877
- Manufacturer Ref. :
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This peptide, derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-ß, thus preventing the progression of hepatic damage and fibrosis.
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Citations
Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-Beta activation by vascular smooth muscle cells: implications for in-stent restenosis
Vasc Res . 2009 Dec 16 ; 47(4) 309 | DOI : 10.1159/000265565.
- MA. Pallero
Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-β activity in vascular smooth muscle cells.
Am J Physiol Cell Physiol . 2010 Feb 17 ; 298(5) C1188 | DOI : 10.1152/ajpcell.00330.2009.
- S. Wang
LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction.
Archives Pharmac Res . 2010 Feb 24 ; 33(2) 275 | DOI : 10.1007/s12272-010-0213-6.
- X. Xie
A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.
Am J Pathol . 2007 Sep 01 ; 171(3) 777 | DOI : 10.2353/ajpath.2007.070056.
- S. Belmadani
Thy-1 Expression Regulates the Ability of Rat Lung Fibroblasts to Activate Transforming Growth Factor-β in Response to Fibrogenic Stimuli
Am J Pathol . 2004 Aug 01 ; 165(2) 659 | DOI : 10.1016/s0002-9440(10)63330-5
- Y. Zhou
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.
Pharmaceuticals (Basel). . 2014 May 27 ; 7(6) 662 | DOI : 10.3390/ph7060662
- S. Nashine
Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-beta
J Leukoc Biol. . 2012 Nov 27 ; 93(4) 471 | DOI : 10.1189/jlb.0712324
- J. Willet
Amino acids induce indicators of response to injury in glomerular mesangial cells
Am J Physiol Renal Physiol. . 2003 Mar 18 ; 285(1) F79 | DOI : 10.1152/ajprenal.00419.2002
- R.L. Meek
References
A blocking peptide for transforming growth factor-β1 activation prevents hepatic fibrosis in vivo
J. Hepatol. . 2003 Nov 01 ; 39(5) 742 | DOI : https://doi.org/10.1016/S0168-8278(03)00377-5
- H. Kondou
The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β
J. Biol. Chem. . 1999 May 01 ; 274(19) 13586 | DOI : https://doi.org/10.1074/jbc.274.19.13586
- SM. Ribeiro
- et al