Peptides

VEGFR2/KDR Antagonist - 1 mg

$138.00
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  • Cat.Number : AS-60628
  • Availability :
    In stock

Quantity

This peptide is a specific VEGFR2/KDR heptapeptide antagonist, it binds VEGFR2 (KDR/flk), completely inhibiting VEGF binding to KDR and preventing VEGF-induced angiogenesis in-vivo. It specifically inhibits human endothelial cell proliferation in-vitro and totally abolishes VEGF-induced angiogenesis in-vivo.

Specifications

Chemistry
Sequence one letter code
  • ATWLPPR
Sequence three letter code
  • H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH
Molecular Formula
  • C40H61N11O9
Molecular Mass/ Weight
  • 840
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Selective photodynamic therapy by targeted Verteporfin delivery to experimental choroidal neovascularization mediated by a homing peptide to vascular endothelial growth factor receptor-2.

Arch Ophthalmol . 2004 Jul 01 ; 122(7) 1002 | DOI : 10.1001/archopht.122.7.1002

  • RZ. Renno

Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway.

Invest Ophthalmol Vis Sci . 2013 Feb 18 ; 54(2) 918 | DOI : 10.1167/iovs.12-11291.

  • H. Liu

References

Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis

Embo J . 2000 Mar 03 ; 19(7) 1525 | DOI : https://doi.org/10.1093/emboj/19.7.1525

  • R. Binetruy-Tournaire
  • et al

Vascular Endothelial Growth Factor (VEGF)-D and VEGF-A Differentially Regulate KDR-mediated Signaling and Biological Function in Vascular Endothelial Cells

J. Biol. Chem. . 2004 Aug 01 ; 279(34) 36148 | DOI : https://doi.org/10.1074/jbc.M401538200

  • H. Jia
  • et al

Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cells

Gynecol. Oncol. . 2004 Jul 01 ; 94(1) 125 | DOI : https://doi.org/10.1016/j.ygyno.2004.03.038

  • F. Ye
  • et al

Selective Targeting of Verteporfin to Choroidal Neovascularization Mediated by a Homing Peptide to VEGF-R2

Invest. Ophthalmol. Vis. Sci. . 2002 Dec 01 ; 42 3977

  • R. Renno
  • et al

Selective Inhibition of Vascular Endothelial Growth Factor (VEGF) Receptor 2 (KDR/Flk-1) Activity by a Monoclonal Anti-VEGF Antibody Blocks Tumor Growth in Mice

Cancer Res. . 2000 Sep 01 ; 60(18) 5117 | DOI : PubMed 11016638

  • R. Brekken
  • et al