IMG-EN-AS-62621-01.jpg
Peptides

WP9QY, TNF-a Antagonist - 1 mg

$177.00
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  • Cat.Number : AS-62621
  • Availability :
    In production

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This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.

Specifications

Chemistry
Sequence one letter code
  • YCWSQYLCY (Disulfide bridge: 2-8)
Sequence three letter code
  • H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (Disulfide bridge: 2-8)
CAS registry number
  • 199999-60-5
Molecular Formula
  • C58H73N11O15S2
Molecular Mass/ Weight
  • 1226.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Synthetic construct

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References

A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti–tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis

Arthritis Rheum . 2007 Mar 28 ; 56(4) 1164 | DOI : https://doi.org/10.1002/art.22495

  • H. Saito
  • et al