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Fluorescent Dyes  >  Enzyme Detection Reagents  >>  Caspase 3 (Apopain) Substrate 1r-z, fluorogenic
Product Name Caspase 3 (Apopain) Substrate 1r - z, fluorogenic
(Z - DEVD)2 - Rh110
Size 5 mg
Catalog # AS-60304-5
US$ $350
Description

Rh110 (rhodamine 110)-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities. Cleavage of Rh110 peptides by caspases generates strongly fluorescent Rh110 that is monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments.

Caspase-3 substrate and caspase-7 substrate
Detailed Information Datasheet
Storage -20°C desiccated and protected from light
References Gurtu V, et al. (1997). Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 251, 98-102; Martins LM, et al. (1997). Activation of multiple interleukin-1 ? converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272, 7421-30.
Molecular Weight 1518.4
Sequence
(One-Letter Code)		 (Z-DEVD)2-Rh110
Sequence
(Three-Letter Code)		 z - (Asp - Glu - Val - Asp)2 - Rh110
Product Citations Monian, P. et al. (2015). The cellular apoptosis susceptibility protein (CAS) promotes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis and cell proliferation J. Biol. Chem 291:2379 doi: 10.1074/jbc.M115.685008

Sanchez-Gonzalez, PD. et al. (2011). Effects of deferasirox on renal function and renal epithelial cell death. Toxicol Lett 203 154. doi:10.1016/j.toxlet.2011.03.018
     
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