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Peptides

Caspase 3 (Apopain) Substrate 1r-z, fluorogenic - 5 mg

$430.00
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  • Cat.Number : AS-60304-5
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Caspase-3 substrate and caspase-7 substrate;
Rh110 (rhodamine 110)-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities. Cleavage of Rh110 peptides by caspases generates strongly fluorescent Rh110 that is monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments.

Specifications

Chemistry
Sequence one letter code
  • (Z-DEVD)2-Rh110
Sequence three letter code
  • z-(Asp-Glu-Val-Asp)2-Rh110
CAS registry number
  • 223538-61-2
Molecular Formula
  • C72H78N10O27
Molecular Mass/ Weight
  • 1515.5
Properties
Absorbance (nm)
  • 488
Emission (nm)
  • 520
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Effects of deferasirox on renal function and renal epithelial cell death.

Toxicol Lett . 2011 Mar 23 ; 203(2) 154 | DOI : 10.1016/j.toxlet.2011.03.018

  • P.D. Sánchez-González

The cellular apoptosis susceptibility protein (CAS) promotes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis and cell proliferation

J Biol Chem . 2016 Jan 29 ; 291(5) 2379 | DOI : 10.1074/jbc.M115.685008

  • P. Monian

References

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

J Biol Chem . 1997 Mar 01 ; 272(11) 7421 | DOI : https://doi.org/10.1074/jbc.272.11.7421

  • LM. Martins
  • et al