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Peptides

Beta-Amyloid (1-40) • HCl

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  • Cat.Number : AS-20698
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All the HCl salt forms of Aß (1-40), Aß (25-35) and D-Ser26 Aß (25-35), take the ß-structure within a few hours in PBS. They form fibrils, exert toxic effects on hippocampal cultured neurons and suppress MTT reduction activity of non-neuronal (HeLa) cells without cytotoxicity.

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Citations

Transcriptional Profile of HIV-induced Nuclear Translocation of Amyloid β in Brain Endothelial Cells.

Arch Med Res . 2014 Nov 24 ; 45(8) 744 | DOI : 10.1016/j.arcmed.2014.11.003.

  • IE. András

Reversibility of β-amyloid self-assembly: Effects of pH and added salts assessed by fluorescence photobleaching recovery.

Biomacromolecules . 2010 Feb 08 ; 11(2) 341 | DOI : 10.1021/bm900833b.

  • NJ. Edwin

Inhibition of Alzheimer's amyloid-β peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin.

Neurobiol Aging . 2005 Jun 01 ; 26(6) 849 | DOI : 10.1016/j.neurobiolaging.2004.08.003.

  • H. Qiao

Amyloid beta peptide‐induced cerebral neuronal loss is mediated by caspase‐3 in vivo.

J Neuropathol Exp Neurol . 2004 Mar 01 ; 63(3) 255 | DOI : 10.1093/jnen/63.3.255

  • H. Takuma

RS‐4252 Inhibits Amyloid β‐Induced Cytotoxicity in HeLa Cells.

Pharmacol Toxicol . 2003 Jun 26 ; 93(1) 29 | DOI : 10.1034/j.1600-0773.2003.930104.x.

  • S. Nishimura

Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins.

FASEB J . 2002 Apr 01 ; 16(6) 601 | DOI : 10.1096/fj.01-0530fje.

  • J-I. Kakimura

Amyloid β-peptide alters the distribution of early endosomes and inhibits phosphorylation of Akt in the presence of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT).

Mol Brain Res . 2002 Oct 15 ; 106(1-2) 94 | DOI : 10.1016/S0169-328X(02)00416-3.

  • T. Kubo

References

Neurotoxicity of beta-amyloid

Nippon Yakurigaku Zasshi. . 2000 Feb 01 ; 115 67 | DOI : 10.1254/fpj.115.67

  • I. Kaneko
  • et al