IMG-EN-AS-20791-01.jpg
Peptides

Magainin 1

$127.00
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  • Cat.Number : AS-20791
  • Availability :
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Magainins are peptide antibiotics with antibacterial and antiparasitic activities, originally extracted from the skin of Xenopus laevis. Magainin 1 and 2 are closely related peptides of 23 amino acids each and differ by two substitutions. These antimicrobial peptides have broad-spectrum, non-specific activity against a wide range of micro-organisms, including viruses, gram-positive and gram-negative bacteria, protozoa, yeasts and fungi, and may also be hemolytic and cytotoxic to cancer cells. Magainin 1 is a bactericide. Both Magainin 1 and 2 exhibit inhibitory action toward Herpes simplex virus type 1(HSV-1) and HSV-2.

Specifications

Chemistry
Sequence one letter code
  • GIGKFLHSAGKFGKAFVGEIMKS
Sequence three letter code
  • H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH
CAS registry number
  • 108433-99-4
Molecular Formula
  • C112H177N29O28S
Molecular Mass/ Weight
  • 2410
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Xenopus

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Citations

Antimicrobial peptides as new recognition molecules for screening challenging species.

Sens Actuators B Chem. . 2007 Jan 30 ; 121(1) 150 | DOI : 10.1016/j.snb.2006.09.044.

  • NV. Kulagina

Antimicrobial peptide inhibition of Porphyromonas gingivalis 381-induced hemagglutination is improved with a synthetic decapeptide.

Peptides . 2009 Aug 08 ; 30(12) 2161 | DOI : 10.1016/j.peptides.2009.07.027.

  • DR. Dixon

Antimicrobial Peptides for Plaque Control.

Advances in Dental Research . 2009 Jul 31 ; 21(1) 57 | DOI : 10.1177/0895937409335627

  • P. Leung

Characterization of a Campylobacter jejuni VirK Protein Homolog as a Novel Virulence Determinant

Infect Immun . 2009 Sep 21 ; 77(12) 5428 | DOI : 10.1128/​IAI.00528-09.

  • V. Novik

Antimicrobial Peptides for Detection of Bacteria in Biosensor Assays.

Anal Chem . 2005 Oct 01 ; 77(19) 6504 | DOI : 10.1021/ac050639r

  • NV. Kulagina

References

Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus

Int J Antimicrob Agents . 2004 Apr 01 ; 23(4) 23(4) | DOI : 23(4)

  • A. Matanic
  • V. Castilla

In vitro activity of the antimicrobial peptide magainin 1 against Bonamia ostreae, the intrahemocytic parasite of the flat oyster Ostrea edulis

Mol Mar Biol Biotechnol . 1994 Dec 01 ; 3(6) 327 | DOI : 7704115

  • A. Morvan
  • et al

Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor

PNAS . 1987 Aug 01 ; 84(15) 5449 | DOI : https://doi.org/10.1073/pnas.84.15.5449

  • M. Zasloff
  • et al