IMG-EN-AS-60210-5-01.jpg
Peptides

DNA-PK Substrate - 5 mg

$445.00
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  • Cat.Number : AS-60210-5
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    In production

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A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activity

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EPPLSQEAFADLWKK
Sequence three letter code
  • H-Glu-Pro-Pro-Leu-Ser-Gln-Glu-Ala-Phe-Ala-Asp-Leu-Trp-Lys-Lys-OH
Molecular Formula
  • C82H123N19O24
Molecular Mass/ Weight
  • 1759.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Autoantibodies to DNA-dependent protein kinase. Probes for the catalytic subunit.

J Clin Invest . 1996 Mar 15 ; 97(6) 1417 | DOI : https://doi.org/10.1172/JCI118562.

  • A. Suwa
  • et al

Biochemical evidence for Ku‐independent backup pathways of NHEJ

Nucleic Acids Res . 2003 Sep 15 ; 31(18) 5377 | DOI : https://doi.org/10.1093/nar/gkg728

  • H. Wang
  • et al

Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3′,5′-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor β and Apoptosis: Involvement of Mitochondria

Clinical Cancer Res . 1999 Jul 01 ; 5(7) 1892 | DOI : PubMed: 10430097

  • RK. Srivastava
  • et al

Selective inhibition of the DNA‐dependent protein kinase (DNA‐PK) by the radiosensitizing agent caffeine

Nucleic Acids Res . 2004 Mar 15 ; 32(6) 1967 | DOI : https://doi.org/10.1093/nar/gkh508

  • W. Block
  • et al