A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activity
Ref: Wang, H. et al. Nucleic Acids Res. 31, 5377 (2003); Srivastava, RK. et al. Clinical Cancer Res. 5, 1892 (1999); Suwa, A. et al. J. Clin. Invest. 97, 1417 (1996); Block, W. et al. Nucleic Acids Res. 2, 1967 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Pro - Pro - Leu - Ser - Gln - Glu - Ala - Phe - Ala - Asp - Leu - Trp - Lys - Lys - OH