This fibronectin-binding peptide, derived from the second type I repeat of thrombospondin, is an inhibitor of the fibronectin-mediated interactions of cells with collagen in the extracellular matrix. It is completely conserved in the second type I repeats of mouse and human thrombospondin-1 and thrombospondin-2 from mouse and chicken.
Ref: Sipes, J. J. Cell Biol. 121, 469 (1993); Shultz-Cherry, S. et al. J. Biol. Chem. 270, 7304 (1995).