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Peptides  >  Angiotensins and Related Peptides  >>  Angiotensin II, human

Product Name Angiotensin II, human
Size 5 mg
Catalog # AS-20633
US$ $34
Purity % Peak Area By HPLC ≥ 95%

The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Ref: Cobb, C. et al. Gen. Comp. Endocrinol. 127, 8 (2002); Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Kinoshita, A. et al. J. Biol. Chem. 266, 19192 (1991); Spyroulias, G. et al. Eur. J. Biochem. 270, 2163 (2003).
Molecular Weight 1046.2
(One-Letter Code)
(Three-Letter Code)
H - Asp - Arg - Val - Tyr - Ile - His - Pro - Phe - OH
Product Citations Sargaeva, NP. et al. (2011). Differentiating N-terminal aspartic and isoaspartic acid residues in peptides. Anal Chem 10.1021/ac201223d.

Zhang, C. et al. (2011). Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase–endothelial nitric oxide synthase pathway in rats. Clin Exp Pharmacol Physiol 38, 55. doi: 10.1111/j.1440-1681.2010.05461.x.

Badu-Tawaih, A. & Cooks, RG. (2010). Enhanced ion signals in desorption electrospray ionization using surfactant spray solutions. J Am Soc Mass Spectrom 21, 1423.

Zhao, Y. et al. (2010). Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway. J Cell Physiol 225, 168. doi: 10.1002/jcp.22209.

Berkout, V. et al. (2009). Fragmentation of Singly Protonated Peptides via Interaction with Metastable Rare Gas Atoms. Anal Chem 81, 725. doi: 10.1021/ac802214e.

Kim, J. et al. (2009). Blockade of angiotensin II attenuates VEGF-mediated blood–retinal barrier breakdown in diabetic retinopathy. J Cerebral Blood Flow Metab 29, 621. doi: 10.1038/jcbfm.2008.154. Epub 2008 Dec 24.

Rauniyar, N. et al. (2009). Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation. Anal Chem 81, 782. doi: 10.1021/ac802015m.

Gardner, M. et al. (2008). Chromogenic cross-linker for the characterization of protein structure by infrared multiphoton dissociation mass spectrometry. Anal Chem 80, 4807. doi: 10.1021/ac800625x.

Zhao, Y. et al. (2008). Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells. Acta Biochim Biophys Sin 40, 304. doi: 10.1111/j.1745-7270.2008.00402.x.

Chipitsyna, G. et al. (2007). Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and β-cells. Endocrinology 148, 2198.

Zhang, S. et al. (2007). Site-specific Pyrolysis-induced cleavage at aspartic acid residue in peptides and proteins. J Proteome Res 6, 1700. doi: 10.1021/pr060648w.

Zhang, S. et al. (2007). On-probe pyrolysis desorption electrospray ionization (DESI) mass spectrometry for the analysis of non-volatile pyrolysis products. J Anal Appl Pyrolysis 80, 353. doi: 10.1016/j.jaap.2007.04.005.

Crowe, MC. et al. (2004). Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociationof peptides in a quadrupole ion trapwith selective IRMPD of phosphopeptides. J Am Soc Mass Spectrom 15, 1581.
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