The amino acid sequence of NPW23 is completely identical to that of the N-terminal 23 residues of NPW30. Synthetic NPW23 and NPW30 activated and bound to both GPR7 and GPR8 at similar effective doses. The europeptide W acts as a mediator of the central control of feeding and the neuroendocrine system.
Ref: Shimomura, Y. et al. J .Biol. Chem. 277, 35826 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Trp - Tyr - Lys - His - Val - Ala - Ser - Pro - Arg - Tyr - His - Thr - Val - Gly - Arg - Ala - Ala - Gly - Leu - Leu - Met - Gly - Leu - OH