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Fluorescent Dyes  >  Enzyme Detection Reagents  >>  TACE FRET Substrate I

Product Name TACE FRET Substrate I
(DABCYL - Leu - Ala - Gln - Ala - Val - Arg - Ser - Ser - Ser - Arg - EDANS)
Size 5 mg
Catalog # AS-25349
US$ $946

TACE FRET substrate I is derived from the cleavage sequence of pro-TNFa recognized by TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.

Minimum Purity: 95%

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C desiccated and protected from light
References Becker BF, et al. (2002). Application of peptides containing the cleavage sequence of pro-TNFalpha in assessing TACE activity of whole cells. Biol Chem 383, 1821-6, Mohler KM, et al. (1994). Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370, 218-20
Molecular Weight 1573.6
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