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Peptides  >  Signal Transduction Peptides  >>  JAG-1 (188-204), Jagged-1 (188-204), Notch Ligand, DSL Peptide

Product Name JAG - 1 (188 - 204), Jagged - 1 (188 - 204), Notch Ligand, DSL Peptide
Size 1 mg
Catalog # AS-61298
US$ $154
Purity % Peak Area By HPLC ≥ 95%

This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-κB activation.

Related Product: Jagged-1, scrambled, cat# 64239

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Nickoloff, B. et al. Cell Death Different. 9, 842 (2002).
Molecular Weight 2107.4
(One-Letter Code)
(Three-Letter Code)
H - Cys - Asp - Asp - Tyr - Tyr - Tyr - Gly - Phe - Gly - Cys - Asn - Lys - Phe - Cys - Arg - Pro - Arg - OH
Product Citations Yamamoto, Y. et al. (2016). Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion. Nat Commun 7, 10380. doi: 10.1038/ncomms10380.

Xie, K. et al. (2015). Notch signaling activation is critical to the development of neuropathic pain. BMC Anesthesiol 15, 41. doi: 10.1186/s12871-015-0021-0.

Wang, X. et al. (2015). Cloning and Variation of Ground State Intestinal Stem Cells Nature 522(7555) 173-178. doi: 10.1038/nature14484

Yamamura, H. et al. (2014). Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2 entry in human pulmonary arterial smooth muscle cells Am J Physiol Cell Physiol 306, C871. doi: 10.1152/ajpcell.00221.2013.

Cioff, S. et al. (2013). Tbx1 regulates brain vascularization. Hum Mol Genet doi: 10.1093/hmg/ddt400.

Onuma, K. et al. (2013). Genetic reconstitution of tumorigenesis in primary intestinal cells. PNAS 110, 11127. doi: 10.1073/pnas.1221926110.

Wang, F. et al. (2013). Isolation and Characterization of Intestinal Stem Cells Based on Surface Marker Combinations and Colony-Formation Assay. Gastroenterol 145, 383. doi: 10.1053/j.gastro.2013.04.050.

VanDussen, KL. et al. (2012). Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 139, 488. doi: 10.1242/dev.070763.

Van Landeghem, L. et al. (2012). Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol 302, G1111. doi: 10.1152/ajpgi.00519.2011.

Fox, RG. et al. (2012). Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol 302, G914. doi: 10.1152/ajpgi.00402.2011.

Ramalingam, S. et al. (2012). Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture. Am J Physiol Gastrointest Liver Physiol 302, G10. doi: 10.1152/ajpgi.00277.2011.

Yao, H. et al. (2011). Platelet-derived growth factor B chain is a novel target gene of cocaine-mediated Notch1 signaling: Implications for HIV-associated neurological disorders. J Neurosci 31, 12449. doi: 10.1523/JNEUROSCI.2330-11.2011.

Gracz, AD. et al. (2010). Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol 298, G590. doi: 10.1152/ajpgi.00470.2009.

Ma, X-B. et al. (2009). Expression and role of Notch signalling in the regeneration of rat tracheal epithelium. Cell Proliferation 42, 15.

Sainson, RCA. et al (2005). Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB Journal 19, 1027.
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