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Peptides  >  FRET Peptides  >>  Cls Substrate, C2 (Abz/Dnp)

Product Name Cls Substrate, C2 (Abz/Dnp)
2Abz - SLGRKIQIK(Dnp) - NH2
Size 1 mg
Catalog # AS-61315
US$ $181
Purity % Peak Area By HPLC ≥ 95%

This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Kerr, F. et al. J. Biol. Chem. 280, 39510 (2005), S. Nagasawa, and R. Stroud PNAS 74, 2998 (1977).
Molecular Weight 1326.5
(One-Letter Code)
(Three-Letter Code)
2Abz - Ser - Leu - Gly - Arg - Lys - Ile - Gln - Ile - Lys(Dnp) - NH2
Product Citations Brannon, R. J. et al. (2015). Antimicrobial peptide conformation as a structural determinant of omptin protease specificity JB 197 doi: 10.1128/JB.00469-15

Thomassin, JL. et al. (2012). OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation ofhuman LL-37 Infect Immun 80, 483. doi: 10.1128/​IAI.05674-11 .
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