IMG-EN-AS-62522-01.jpg
Peptides

Adeno-Associated Virus Epitope 2 (AAV2) - 1 mg

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  • Cat.Number : AS-62522
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    In stock

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This peptide is the capsid derived immunodominant adeno-associated virus 2 (AAV2), CD8 T cell epitope. Liver toxicity observed in a clinical trial of AAV2 delivered systemically to patients with hemophilia was ascribed to killing of vector-transduced hepatocytes by capsid-specific T-cells.

Specifications

Chemistry
Sequence one letter code
  • VPQYGYLTL
Sequence three letter code
  • H-Val-Pro-Gln-Tyr-Gly-Tyr-Leu-Thr-Leu-OH
Molecular Formula
  • C51H76N10O14
Molecular Mass/ Weight
  • 1053.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • AAV

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References

CD8(+) T-cell responses to adeno-associated virus capsid in humans

Nature Medicine . 2007 Mar 18 ; 13(4) 419 | DOI : 10.1038/nm1549

  • F. Mingozzi
  • et al

Cross-Presentation of Adeno-Associated Virus Serotype 2 Capsids Activates Cytotoxic T Cells But Does Not Render Hepatocytes Effective Cytolytic Targets

Therapy . 2007 Mar 01 ; 18(3) 185 | DOI : https://doi.org/10.1089/hum.2007.001

  • L. Wang
  • et al