This peptide is a potent formyl peptide receptor-like 1 (FPRL1) specific agonist. MMK-1 serves as a strong chemotaxis and mobilizes calcium for activating human monocytes, neutrophils, and FPRL-1 transfected human embryonic kidney 293 cells. It also stimulates human monocytes to increase pertusis toxin-sensitve production of inflammatory cytokines.
Hu, JY. et al. J Leukoc Biol70, 155 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Glu - Ser - Ile - Phe - Arg - Ser - Leu - Leu - Phe - Arg - Val - Met - OH