This is amino acids 54 to 65 fragment of hirudin, a 65-residue peptide. Hirudin is found in the saliva of the leech Hirudo medicinalis. The unsulfated peptide corresponding to the C-terminal of hirudin has demonstrated efficacy in inhibiting clot formation in vitro. This hirudin fragment (desulfated) causes contraction of canine coronary arteries which is attenuated by calcium-channel blockers. Hirudin (54-65), sulfated is cat# 62986.
Sorajja, P. et al. J. Am. Coll. Cardiol. 31, 53 (1998); Krstenansky, J. L. FEBS Lett. 211, 10 (1987).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Asp - Phe - Glu - Glu - Ile - Pro - Glu - Glu - Tyr - Leu - Gln - OH