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Peptides  >  Retinoid Binding Protein  >>  IRBP (1-20), human

Product Name IRBP (1 - 20), human
GPTHLFQPSLVLDMAKVLLD
Size 1 mg
Catalog # 62297
US$ $121
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the interphotoreceptor matrix between the neural retina and the retinal pigment epithelium. Human IRBP peptide 1-20 contains a major epitope for the H-2b haplotype. Immunization with IRBP (1 – 20) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU) disease. The pathology of disease induced by the peptide, or by adoptive transfer of cells specific to the peptide, is similar to that induced by the whole IRBP protein.

Storage -20°C
References Avichezer, D. et al. Invest. Ophthalmol. Visual Sci. 41, 127 (2000).
Molecular Weight 2194.6
Sequence
(One-Letter Code)
GPTHLFQPSLVLDMAKVLLD
Sequence
(Three-Letter Code)
H - Gly - Pro - Thr - His - Leu - Phe - Gln - Pro - Ser - Leu - Val - Leu - Asp - Met - Ala - Lys - Val - Leu - Leu - Asp - OH
Product Citations "An, F. et al. (2009). Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 50, 3778."
"Pennesi, G. et al. (2003). A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest 111, 1171."
     
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