IMG-EN-AS-60183-1-01.jpg
Peptides

IRBP, Interphotoreceptor Retinoid Binding Protein Fragment

$164.00
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  • Cat.Number : AS-60183-1
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This 20-residue peptide, a major pathogenic T-cell epitope (161–180), is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP). It has been shown to induce posterior uveitis (EAU).

Specifications

Chemistry
Sequence one letter code
  • SGIPYIISYLHPGNTILHVD
Sequence three letter code
  • H-Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp-OH
Molecular Formula
  • C103H157N25O29
Molecular Mass/ Weight
  • 2209.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, macaque

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Citations

Low dose rapamycin exacerbates autoimmune experimental uveitis.

Plos One . 2012 May 04 ; 7(5) e36589 | DOI : 10.1371/journal.pone.0036589

  • Z. Zhang

Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis.

Invest Ophthalmol Vis Sci. . 2009 May 14 ; 50(8) 3778 | DOI : 10.1167/iovs.08-3264

  • F. An

Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype.

J Immunol. . 2007 May 01 ; 178(9) 5578 | DOI : 10.4049/jimmunol.178.9.5578

  • Jung Tan

References

Antigen/MHC Class II/Ig Dimers for Study of Uveitogenic T Cells: IRBP p161–180 Presented by both IA and IE Molecules

Invest Ophthalmol Vis Sci . 2005 Oct 01 ; 46(10) 3769 | DOI : https://doi.org/10.1167/iovs.05-0187

  • Z. Karabekian
  • et al

Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype

Invest Ophthal Vis Sci . 1995 May 01 ; 36(5) 946 | DOI : 7706044

  • P. Silver
  • et al

Immunoregulatory Role of Ocular Macrophages: The Macrophages Produce RANTES to Suppress Experimental Autoimmune Uveitis

J Immunol . 2003 Sep 15 ; 171(5) 2652 | DOI : https://doi.org/10.4049/jimmunol.171.5.2652

  • K. Sonoda
  • et al

Transgenic Expression of a Soluble Complement Inhibitor Decreases the Incidence and Severity of Murine Experimental Autoimmune Uveitis

ARVO Meeting Abstracts . 2002 Dec 01 ; 43(13) 2281

  • RW. Read
  • SR. Barnum