IRBP (1-20), human - 1 mg
- Cat.Number : AS-62297
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This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the interphotoreceptor matrix between the neural retina and the retinal pigment epithelium. Human IRBP peptide 1-20 contains a major epitope for the H-2b haplotype. Immunization with IRBP (1 – 20) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU) disease. The pathology of disease induced by the peptide, or by adoptive transfer of cells specific to the peptide, is similar to that induced by the whole IRBP protein.
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IRBP, Interphotoreceptor Retinoid Binding Protein Fragment
Citations
Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis.
Invest Ophthalmol Vis Sci. . 2009 May 14 ; 50(8) 3778 | DOI : 10.1167/iovs.08-3264
- F. An
A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
J Clin Invest. . 2003 Apr 15 ; 111(8) 1171 | DOI : 10.1172/JCI200315155
- G. Pennesi
References
Identification of a New Epitope of Human IRBP that Induces Autoimmune Uveoretinitis in Mice of the H-2b Haplotype
Invest Ophthalmol Visual Sci . 2000 Jan 01 ; 41(1) 127 | DOI : 10634611
- D. Avichezer
- et al