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Peptides  >  RGD Peptides  >>  Integrin-Binding Site, GRGDNP

Product Name Integrin - Binding Site, GRGDNP
GRGDNP
Size 1 mg
Catalog # 62049
US$ $61
Purity % Peak Area By HPLC ≥ 95%
Description

This RGD-containing sequence is integrin-binding site. RGD peptides are found in both extracellular matrix (ECM) (e.g., collagen, osteopontin, fibronectin, and vitronectin) and non-ECM proteins (e.g., disintegrins). RGD-containing peptides are recognized by several integrins. This peptide targets both alphavbeta3 and alpha5beta1 integrins. Interaction of the RGDN sequence with endothelial alpha5beta1 integrin causes endothelin-mediated arteriolar vasoconstriction. This peptide influences the IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) activation. It also controls the cardiac contractile function.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Mogford, J. et al. J. Clin. Invest. 100, 1647 (1997); Sasamoto, A. et al. Am. J. Physiol. Cell. Physiol. 288, C1012 (2005); Sarin, V. et al. J. Physiol. 564, 603 (2005).
Molecular Weight 614.6
Sequence
(One-Letter Code)
GRGDNP
Sequence
(Three-Letter Code)
H - Gly - Arg - Gly - Asp - Asn - Pro - OH
     
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