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Peptides  >  p53 Peptides  >>  [Lys(Ac)382]-p53 (372-389), biotin labeled, amide

Product Name [Lys(Ac)382] - p53 (372 - 389), biotin labeled, amide
Biotin - LC - KKGQSTSRHK - K(Ac) - LMFKTEG - NH2
Size 0.25 mg
Catalog # AS-65046-025
US$ $115
Purity % Peak Area By HPLC ≥ 95%

This is an amidated peptide derived from amino acid residues 372-389 of human p53 tumor suppressor protein with acetylation at Lys382. It is biotinylated at its N-terminus through a 6-carbon LC linker. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.

Storage -20C
References Kubbutat, M. et al. Lett. Nature 387, 299 (1997); Li, M. et al. J. Biol. Chem. 277, 50607 (2002).
Molecular Weight 2472
(One-Letter Code)
(Three-Letter Code)
Biotin - LC - Lys - Lys - Gly - Gln - Ser - Thr - Ser - Arg - His - Lys - Lys(Ac) - Leu - Met - Phe - Lys - Thr - Glu - Gly - NH2
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