Recombinant Proteins for Neuroscience Research


AnaSpec, EGT Group is pleased to supply recombinant proteins to complement our wide selection of Neuroscience related peptides, antibodies and assay kits. We offer α-Synuclein and DJ-1 proteins for Parkinson's Disease (PD) research; MOG (Myelin Oligodendrocyte Glycoprotein) and β-Synuclein for MS/EAE research. Additionally, α-Synuclein is available as endotoxin-free (EndoFree). α-Synuclein labeled with a green fluorescent dye (HiLyte™ Fluor 488, Ex/Em=490/520 nm) or a biotin is also available.

Parkinson's Disease (PD) Research:

alpha-Synuclein (1-140)

  • A major component of Lewy bodies in the affected neurons in Parkinson's disease (1-4).
  • This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence (1-4).
  • Sequence (Accession# NP_000336) corresponds to the full length human alpha-synuclein protein without an affinity tag and was expressed in E. coli.
  • Each lot tested for aggregation
  • Available as EndoFree (less than 0.1 EU per μg/protein as tested by LAL method).

alpha_synuclein
Table 1. Listing of AnaSpec's alpha-Synuclein recombinant proteins.

Product
Size

Catalog #

EndoFree Recombinant Human alpha-Synuclein Protein NEW

100 μg
500 μg
1000 μg

55555-100
55555-500
55555-1000

Recombinant Human alpha-Synuclein (1-140)

500 μg
1 mg

55456-500
55456-1000

Recombinant Human alpha-Synuclein (1-140), biotin labeled

200 μg

55581

Recombinant Human alpha-Synuclein (1-140), HiLyte™ Fluor 488 labeled (Ex/Em=490/520 nm)

200 μg

55457

Related Product:

DJ-1 (PARK7) Protein

  • Also known as PARK7 (Parkinson disease protein 7).
  • It is a 189-amino acid protein that is ubiquitously expressed in many organs including brain, liver, kidney, pancreas, heart, and others (5-9).
  • Although DJ-1 was originally discovered as a novel oncogene product, it was found to play several other roles in biological processes. This includes the regulation of RNA binding activity, fertility, anti-oxidative stress, and is linked to the early onset of Parkinson disease when mutated (5-9).
  • Sequence (Accession# NP_001116849) corresponds to the full length human DJ-1 protein ±N-terminal GST tag and was expressed in E. coli.

DJ-1

Table 2. Listing of AnaSpec's DJ-1 (PARK7) recombinant protein, with and without a GST tag.

Product
Size

Catalog #

DJ-1 (PARK7) Protein NEW

10 μg
100 μg
500 μg

72219-10
72219-100
72219-500

DJ-1 (PARK7) Protein, Human, GST tagged (GST-DJ-1) NEW

10 μg
100 μg
500 μg

72220-10
72220-100
72220-500

Related Product:

Multiple Sclerosis (MS) & EAE (Experimental autoimmune encephalomyelitis) Research:

MOG (1-125), Myelin Oligodendrocyte Glycoprotein (1-125)

  • A member of the immunoglobulin superfamily and is expressed exclusively in central nervous system (CNS).
  • Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys (10-14).
  • Human (Accession# CAQ10087), mouse (Accession# NP_034944) and rat (Accession# CAE84068) sequences were derived from the extracellular domain of MOG and were expressed in E. coli. These recombinant proteins contain a 6x His tag.
  • Tested for EAE induction

MOG
Table 3. Listing of AnaSpec's human, mouse and rat MOG (1-125) recombinant proteins.