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Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH and Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH are useful building blocks for syntheses of peptides containing the GlcNAc modification of serines and threonines, respectively. The addition of β-N-acetylglucosamine (GlcNAc) to the hydroxyl group of serines or threonines generating O-linked β-N-acetylglucosamine (O-GlcNAc) serines or threonines is one kind of post-translational modification (PTM) found in proteins.^1,2 This O-GlcNAcylation reversible modification directly competes with phosphorylation of these two amino acids.^2,3

AnaSpec provides a suite of PTM amino acid building blocks to the epigenetic research community. These Fmoc amino acids that we offer to our customers are the very same amino acids that we use daily in our own manufacturing facilities.

PTM Amino Acids

Glycosylated

Phosphorylated

Acetylated

Methylated

Citrullinated

To view AnaSpec's extensive collection of unusual amino acids, please click here.

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Glycosylated (GlcNac) Serine & Threonine

Product

Size

Catalog #

Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH NEW
CAS# 160067-63-0

100 mg

250 mg

AS-65495-100

AS-65495-250

Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH NEW
CAS# 160168-40-1

100 mg

250 mg

AS-65494-100

AS-65494-250

Phosphorylated Serines

Product

Size

Catalog #

Fmoc-Ser[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L–phosphoserine
CAS# 158171-14-3

1 g

5 g

25 g

50 g

100 g

1 cartridge

10 cartridges

AS-20419

AS-20420

AS-20420-25

AS-20420-50

AS-20420-100

AS-29869

AS-23219

Fmoc-D-Ser[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-D-phosphoserine

1 g

5 g

AS-60083-1

AS-60083-5

Phosphorylated Threonines

Product

Size

Catalog #

Fmoc-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L-phosphothreonine
CAS# 175291-56-2

1 g

5 g

25 g

50 g

100 g

AS-20835

AS-20836

AS-20836-25

AS-20836-50

AS-20836-100

Fmoc-D-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-D-phosphothreonine

1 g

5 g

AS-60557-1

AS-60557-5

Phosphorylated D-Tyrosine

Fmoc-D- Tyr[PO(OBzl)OH] -OH
N-α-Fmoc-O-benzyl-D-phosphotyrosine

1 g

5 g

AS-61428-1

AS-61428-5

Acetylated Lysines

Product

Size

Catalog #

Fmoc-Lys(Ac)-OH
N-α-Fmoc-N-ε-acetyl-L-lysine
CAS# 159766-56-0
1 g

5 g

AS-22502

AS-23356

Boc-Lys(Ac)-OH
N-α-t-Boc-N-ε-acetyl-L-lysine
CAS# 6404-26-8

1 g

5 g

AS-23084

AS-23085

Methylated (mono, di & tri) Lysines

Product

Size

Catalog #

Fmoc-Lys(Me, Boc)-OH
N-α-Fmoc-N-ε,ε-t-Boc-methyl-L-lysine

0.25 g

1 g

5 g

AS-60327-025

AS-60327-1

AS-60327-5

Fmoc-Lys(Me)2-OH • HCl
Fmoc-Lys(Me)2-OH chloride; Fmoc-Lys(Me)2–OH
CAS# 252049-10-8

250 mg

1 g

AS-28211

AS-28212

Boc-Lys(Me)2-OH
Boc-Nε,ε -dimethyl-L-lysine

250 mg

1 g

AS-60025-025

AS-60025-1

Fmoc-Lys(Me3)-OH chloride
CAS# 201004-29-7

250 mg

500 mg

1 g

AS-53099-F025

AS-53099-F05

AS-53099-F1

Methylated (mono & di- symmetrical & asymmetrical) Arginines

Product

Size

Catalog #

Fmoc-Arg(Me)(Pbf)–OH
CAS# 135616-49-7

0.25 g

1 g

AS-65281-025

AS-65281-1

Fmoc-Arg(Me)2-OH (asymmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (asymmetrical)
CAS# 268564-10-9

250 mg

1 g

AS-26218-F025

AS-26218-F1

Fmoc-Arg(Me)2-OH (symmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (symmetrical)

250 mg

1 g

AS-26217-F025

AS-26217-F1

Citrullinated (Deiminated) Arginines

Product

Size

Catalog #

Fmoc-DL-citrulline

1 g

5 g

AS-26216-F1

AS-26216-F5

Boc-DL-citrulline

1 g

5 g

AS-26216-B1

AS-26216-B5

Fmoc-L–citrulline
CAS# 133174-15-9

1 g

5 g

AS-21359

AS-21361

Boc-L–citrulline
CAS# 45234-13-7

1 g

5 g

AS-26215-B1

AS-26215-B5

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Reference:

Love, DC. & JA. Hanover, Sci STKE 2005, re 13 (2005).

Hart, GW. et al. Nature 446, 1017 (2007).

Hart, GW. et al. Glycobiol 6, 711 (1996).