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Fmoc-Ser & Thr (GlcNac) for PTM Research

Untitled Document

Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH and Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH are useful building blocks for syntheses of peptides containing the GlcNAc modification of serines and threonines, respectively. The addition of β-N-acetylglucosamine (GlcNAc) to the hydroxyl group of serines or threonines generating O-linked β-N-acetylglucosamine (O-GlcNAc) serines or threonines is one kind of post-translational modification (PTM) found in proteins.^1,2 This O-GlcNAcylation reversible modification directly competes with phosphorylation of these two amino acids.^2,3

AnaSpec provides a suite of PTM amino acid building blocks to the epigenetic research community. These Fmoc amino acids that we offer to our customers are the very same amino acids that we use daily in our own manufacturing facilities.

PTM Amino Acids

Glycosylated

Phosphorylated

Acetylated

Methylated

Citrullinated

To view AnaSpec's extensive collection of unusual amino acids, please click here.

Request a free price quotation of custom PTM Peptides

Glycosylated (GlcNac) Serine & Threonine

Product

Size

Catalog #

Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH NEW
CAS# 160067-63-0

100 mg

AS-65495-100

Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH NEW
CAS# 160168-40-1

100 mg

AS-65494-100

Phosphorylated Serines

Product

Size

Catalog #

Fmoc-Ser[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L–phosphoserine
CAS# 158171-14-3

1 g

5 g

AS-20419

AS-20420

Phosphorylated Threonines

Product

Size

Catalog #

Fmoc-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L-phosphothreonine
CAS# 175291-56-2

1 g

5 g

AS-20835

AS-20836

Fmoc-D-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-D-phosphothreonine

1 g

AS-60557-1

Phosphorylated D-Tyrosine

Product

Size

Catalog #

Fmoc-D- Tyr[PO(OBzl)OH] -OH
N-α-Fmoc-O-benzyl-D-phosphotyrosine

1 g

AS-61428-1

Acetylated Lysines

Product

Size

Catalog #

Fmoc-Lys(Ac)-OH
N-α-Fmoc-N-ε-acetyl-L-lysine
CAS# 159766-56-0
1 g

5 g

AS-22502

AS-23356

Methylated (mono, di & tri) Lysines

Product

Size

Catalog #

Fmoc-Lys(Me, Boc)-OH
N-α-Fmoc-N-ε,ε-t-Boc-methyl-L-lysine

0.25 g

1 g

AS-60327-025

AS-60327-1

Fmoc-Lys(Me)2-OH • HCl
Fmoc-Lys(Me)2-OH chloride; Fmoc-Lys(Me)2–OH
CAS# 252049-10-8

250 mg

1 g

AS-28211

AS-28212

Fmoc-Lys(Me3)-OH chloride
CAS# 201004-29-7

250 mg

1 g

AS-53099-F025

AS-53099-F1

Methylated (mono & di- symmetrical & asymmetrical) Arginines

Product

Size

Catalog #

Fmoc-Arg(Me)(Pbf)–OH
CAS# 135616-49-7

0.25 g

1 g

AS-65281-025

AS-65281-1

Fmoc-Arg(Me)2-OH (asymmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (asymmetrical)
CAS# 268564-10-9

250 mg

1 g

AS-26218-F025

AS-26218-F1

Fmoc-Arg(Me)2-OH (symmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (symmetrical)

250 mg

1 g

AS-26217-F025

AS-26217-F1

Citrullinated (Deiminated) Arginines

Product

Size

Catalog #

Fmoc-L–citrulline
CAS# 133174-15-9

5 g

AS-21361

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Reference:

Love, DC. & JA. Hanover, Sci STKE 2005, re 13 (2005).

Hart, GW. et al. Nature 446, 1017 (2007).

Hart, GW. et al. Glycobiol 6, 711 (1996).