AnaSpec Introduces Suite of Rigorously Validated SOCS Antibodies

SOCS (suppressor of cytokine signaling), as the name implies, belong to a family of proteins that negatively regulates cytokine signaling.1 The structure of each member of the SOCS family consists of a central Src homology 2 (SH2) domain and a SOCS box motif of 40 amino acids on the C-terminus.2,3 The SOCS proteins form part of a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism.4 Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

AnaSpec is pleased to introduce a suite of SOCS antibodies that have been validated in western blots (see Figure below) using cell or tissue lysates. These polyclonal antibodies, raised in rabbits and affinity purified, come in our new economical 50 g format.

ProductSizeCatalog # Approx MW (kDa)Lysate used in WB
Anti-SOCS-1 50 g 28132 24 HEK293 (cat# 29520)
Anti-SOCS-2 50 g 28133 26 Mouse liver (cat# 29509)
Anti-SOCS-3 50 g 28134 27 MCF-7 (cat# 29519)
Anti-SOCS-4 50 g 28135 55 Mouse brain (cat# 29507)
Anti-SOCS-5 50 g 28136 61 A431 (cat# 29514)

Related Products:
  • Primary and secondary (fluorescent and non-fluorescent) antibodies
  • Cell and tissue lysates
  • Custom monoclonal or polyclonal antibody services

  • References:
    1. Krebs, DL and DJ. Hilton. J. Cell Sci. 113, 2813 (2000).
    2. Starr, R. et al. Nature 387, 917 (1997).
    3. Hilton, DJ. et al. Proc. Natl. Acad. Sci USA 95, 114 (1998).
    4. Yoshimura, A. Cytokine Growth Factor Rev. 9, 197 (1998).