Ghrelin Peptides

Ghrelin Peptides Linked to Appetite

In 1999, Kojima and his group (1) reported the discovery of a growth hormone secretagogue that is involved in the release of growth hormone from the anterior pituitary through activation of the growth hormone secretagogue receptor (GHS-R) which they termed Ghrelin (ghre from a Proto-Indo-European root meaning to grow). Ghrelin, a 28-amino-acid peptide hormone produced by the stomach in mammals, is a peptide with an n-octanoyl modification at Ser3 (n-octanoylation is essential for its activity). It stimulates appetite and food intake and decreases fat utilization. The secretion of ghrelin is augmented under conditions of both gastric emptying and filling, and its release stimulated by intestinal hormones (1-5).

  • Human
  • Rat

  • [Des-Octanoyl]-Ghrelin
  • Human
  • Rat

  • Labeled Human Ghrelins - may be used for ligand-receptor intereaction studies (5)
  • Biotin-Labeled

  • References:
    1. Kojima, M. et al. Nature 402, 656 (1999).
    2. Kleinz, MJ. et al. Cardiovasc Res. 69, 227 (2006).
    3. Murakami, N. et al. J. Endocrinol. 174, 283 (2002).
    4. Nishi, Y. et al. Endocrinol. 146, 2709 (2005).
    5. Cowley, MA. et al. Neuron 37, 649 (2003).
    6. Zhang, JV. et al. Science 310, 996 (2005).