SensoLyte® Anti - alpha - Synuclein Human and Rat ELISA Kit
alpha-Synuclein assay kits

As part of our growing portfolio of Parkinson's Disease research tools, our SensoLyte®
α-Synuclein Quantitative ELISA Kits (Human & Rat)
have been designed to accurately and conveniently quantify alpha-Synuclein in cell and tissue lysates, and in body fluids such as plasma.


(Human) ELISA Kit
alpha synuclein elisa human
(Rat) ELISA Kit
AS-55550-R NEW!
alpha synuclein elisa rat
The amount of alpha-Synuclein is quantified following the sandwich ELISA method featuring anti-α-Synuclein specific antibodies directly conjugated to horseradish peroxidase (HRP) for the detection of the captured alpha-Synuclein.
α-Synuclein is considered as a potential biomarker for Parkinson's Disease (PD). Its accurate quantitation could enable earlier detection and accurate diagnoses, thus accelerating therapeutic research and development centered along critical pathogenic mechanisms in PD including aggregation.
  • Requires only 10-20 μl of cell and tissue lysate or body fluids
  • Detects 5 pg/ml of human or rat α-Synuclein
  • Broad Dynamic Range (8-500 pg α-Synuclein/ml)
  • One step assay (samples and detection antibody are added simultaneously)
  • 1 hour assay time at room temp (excluding incubation time)
  • Pre-coated and pre-blocked 96-well strip plate
  • Ready-to-use substrate solution and other assay components

About alpha synuclein
Lewy body in a neuronal cell. Lewy bodies
are abnormal aggregates of α-synuclein
protein observed to develop inside nerve
cells in Parkinson's Disease, Lewy body dementia and other disorders.
α-Synuclein is a central molecule responsible for neurodegenerative effects observed in α-synucleopathies and presents as a major component of Lewy bodies in the affected neurons in Parkinson's disease (Rivers R et al. 2008). It is a 14.5 kDa (140 amino acids long) protein predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions (Rivers R et al. 2008; Irwin JD et al. 2013). It has been hypothesized that α-synuclein exists, under physiological conditions, in random coils. Under pathological conditions, the native protein undergoes misfolding (beyond proteasomal repair) to form dimers/trimers/oligomers which in turn aggregate into higher-ordered protofibril structures. These serve as building blocks for pathological inclusions of α-synuclein in the neurons (Irwin JD et al. 2013).

Products Catalog #/Product Groups
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Related α & β-synuclein Recombinant Proteins
EndoClearPlus™ Recombinant Human α - synuclein
EndoClear™ Recombinant Human α - synuclein
EndoClear™ Recombinant Rat α - synuclein AS-56083-100,500, 1000
EndoClear™ Recombinant Mouse α- Synuclein AS-56082-100,500, 1000
Recombinant Human α - synuclein (1 - 140), HiLyte Fluor™488 labeled
Recombinant Human β - synuclein (1 - 134)
Recombinant Human α - synuclein (1 - 140), biotin labeled
Related Antibodies
Antibodies for Alzheimer's and Parkinsons Disease research Anti-Tau, β-Amyloid, & α-Synuclein
Citations for α-Synuclein ELISA kit
1. Oh SH, et al. (2017). Stem cells translational medicine. 6(3):949-61.

2. Prusiner, B S. (2015). PNAS. 112(38): E5308-E5317.

3. Woerman, A L. (2015). PNAS. 112(35): E4949-E4958.

4. Al-Nimer, MS. et al. (2014). North Am J Med Sci. 6(12): 633-637.

5. Maia, LF. et al. (2013). Sci Transl Med 5, 194re2.

6. Smith, LM. et al. (2012). PloS One 7(12): e52285.