Beta-Amyloid Peptides (1-44, 1-45, 1-46, 1-47, 1-48 & 1-49) – Industry’s First

As the world’s largest provider of amyloid peptides, AnaSpec has always been on the forefront in the development of novel solutions for amyloid-related research. We are pleased to announce our latest breakthrough—the industry’s first commercially available beta-amyloid peptides for sequences 1-44, 1-45, 1-46, 1-47, 1-48, and 1-49.

Amyloid Precursor Protein, APP, is predominantly processed by a-Secretase, producing a 83-amino acid C-terminal fragment, C83; while a small amount is processed by b-Secretase, producing a 99-amino acid C-terminal fragment, C99. Subsequent cleavages of C83 and C99 by g-Secretase produce a 3-kD (p3) protein in the former and a 4-kD (b-amyloid) protein in the latter and a CT57-59 in both fragments.1 The 4-Kd consists of Ab which are 39 to 42 amino acids in length, with Ab 1-42 being the major component of amyloid plaques which accumulates in neurons of Alzheimer’s disease brain.2,3 Novel cleavage sites (e and z) downstream of the g–cleavage site have recently been reported,4,5 which release longer Abs (1-43, 1-45, 1-46 and 1-48).

These longer Abs have been notoriously difficult to make, due to a C-terminus sequence composed primarily of hydrophobic amino acids. Drawing on years of experience synthesizing difficult peptides, AnaSpec is pleased to add these latest Abs to our catalog. With this recent addition, the world’s largest collection of amyloid peptides keeps getting bigger.

ProductSizeCatalog #
Beta - Amyloid (1 – 43) 0.5 mg
1 mg
Beta - Amyloid (1 - 44)0.1 mg61966-01
Beta - Amyloid (1 - 45)0.1 mg61956-01
Beta - Amyloid (1 - 46)0.1 mg62076-01
Beta - Amyloid (1 - 47)0.1 mg61964-01
Beta - Amyloid (1 - 48)0.1 mg61965-01
Beta - Amyloid (1 - 49)0.1 mg61963-01

To request AnaSpec’s latest Peptides catalog, click here

Beta-Amyloid (1-40) and Beta-amyloid (1-42) Sampler Kits:

Fluorophore labeled beta-amyloid peptides have been used in investigating beta-amyloid's aggregation, generation and clearance, microglial activation and phagocytosis. These sampler kits provide a broad selection of peptides for researchers interested in beta-amyloid related experiments.

DHL™ fluorescent beta-amyloid (1-40) & (1-42) sampler kits contain a total of 6 beta-amyloid peptides, including:

  • Two unlabeled control peptides
  • A biotin labeled beta-amyloid peptide
  • Three beta-amyloid peptides with different fluorophore conjugates

  • ProductSizeCatalog #
    DHL™ Fluorescent beta - amyloid (1 - 40) Sampler Kit* NEW1 kit72070
    DHL™ Fluorescent beta - Amyloid (1 - 42) Sampler Kit NEW1 kit72071

    To request AnaSpec’s latest Detection Reagents & Kits catalog, click here

    Related Products:
    Labeled Amyloid Peptides
    All Amyloid Peptides

    1. Selkoe DJ. Nature 399: A23 (1999).
    2. Suzuki, N., et al. Science 264, 1336 (1994).
    3. Iwatsubo, T. et al. Neuron 13, 45 (1994).
    4. Qi-Takahara, Y. et al. J. Neurosci. 25, 436 (2005).