AnaSpec’s collection of antibodies continues to expand
rapidly. We are pleased to present our newest collection of Anti-LC antibodies
that can be used as autophagosome markers.
The mammalian microtubule-associated protein 1 light chain
3 (LC3) is a homolog of the yeast Atg8, a protein that plays a major role
in autophagy. LC3 is a fibronectin mRNA-binding protein linked to mRNA translation.
MAP1-LC3A, -B, & -C are the three human isoforms of MAP1-LC3 which have
been cloned and characterized. These differ in their post-translation modification.
MAP-LC3 proteins are related to cell growth, differentiation and migration
in development and in diseases. AnaSpec’s anti-LC antibodies were referenced
in an article by W. Jackson, et al.3 We are pleased to announce
the availability of anti-LC3B, as well as anti-LC3A (which does not cross-react
with LC3B) and anti-LC3 A/B (which recognizes both A and B isoforms).
1. He, H. et al. J. Biol. Chem. 11, 11 (2003).
2. Zhou, B. et al. J. Clin. Invest. 100, 3070 (1997).
3. Jackson, W. et al. Plos Biol. 3, e156 (2005).