Calcium plays a vital role in the regulation of cardiac contractility, growth and gene expression; consequently, calcium measurement is critical in numerous biological investigations. Fluorescent probes that show spectral responses upon Ca²⁺ binding have enabled researchers to investigate changes in intracellular free Ca²⁺ concentrations using techniques such as fluorescence microscopy, flow cytometry, fluorescence spectroscopy. Most of these fluorescent indicators are derivatives of BAPTA, chelators that incorporate a photo-induced-electron transfer (PET) system responsive to calcium. Instruments, such as FLIPR® and FlexStation^TM have enabled high throughput measurement of calcium for GPCR and ion channel research.

AnaSpec is pleased to highlight a selection of fluorescent Ca²⁺ indicators. These calcium indicators are of the highest quality and are cost-effective. They include UV-excitable and visible light-excitable calcium indicators.

Among the UV-excitable calcium indicators, Fura-2 and Indo-1 are the most commonly used. Rhod-2 is among the most commonly used among the visible light-excitable calcium indicators.

To inquire about licensing opportunities for AnaSpec dyes, please email service@anaspec.com.

Breaking News: BD chooses AnaSpec to manufacture and supply the BD^TM H7, Calcein AM and DiIC12(3) fluorescent dyes.