Caspase Substrates & Inhibitors - Extensive Collection


Caspase Substrates & Inhibitors

Caspases are a family of cysteine-dependent aspartate specific proteases involved in the destruction of cells. In a normal, healthy human being, damaged or mutated cells are regularly destroyed to protect the rest of the body. The induction of caspase-dependent programmed cell death triggers a tightly-controlled cascade of events with the initiator caspases activating effector caspases. These effector caspases not only activate other effector caspases and provide feedback to initiator caspases, they also cleave cellular substrates resulting in morphological changes such as DNA fragmentation, membrane blebbing or apoptotic body formation. These changes, characteristics of apoptosis, ultimately lead to the death of a cell. Caspases, however, may not be the only enzymes involved in cell death; cell death may still occur even if all caspases are all blocked (Reviewed in 1).

Because of their important role in apoptosis and cell signaling, and their identification as drug-screening targets, there is a recognized need for a wide range of caspase substrates and inhibitors. As a leading provider of premium quality peptides and detection reagents, AnaSpec is pleased to offer an extensive list of caspase substrates (including both chromogenic and fluorogenic variations) and caspase inhibitors.

For a full listing of caspase substrates and inhibitors, click here

To request AnaSpec’s 2006-2008 Peptides or 2006-2007 Detection Reagents & Kits Catalogs, click here

Related Products:
  • EnzoLyte™ Caspase Assay Kits
  • CMK inhibitors
  • Caspase p20 subunit (163-175)
  • Smac N7 Protein - Promotes caspase activation in-vitro

  • Reference:
    1. Thornberry, NA. and Y. Lazebnik, Science 281, 1312-1316 (1998).