ß-Secretase Inhibitor 1 - 1 mg
- Cat.Number : AS-23958
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ß-Secretase (BACE1) is a key enzyme involved in the production of Aß peptides found in extracellular amyloid plaques of Alzheimer’s disease (AD). The enzyme has been implicated as an excellent target for anti-amyloid therapy of AD. This statine-based substrate analog, beta-secretase inhibitor P10–P4’ statV, is used in the inhibition of beta-secretase activity from homogenized wild-type mouse cortices and from BACE-purified from human brain.
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References
Conformational analysis of peptides derived from the BRI gene
Spectroscopy . 2001 Jan 20 ; 15 129
- V. Lelyveld
- et al
The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers
J Biol Chem, . 2015 Jul 01 ; 290(27) 16502 | DOI : https://doi.org/10.1074/jbc.M115.652263
- A. Cantlon
- et al
Purification and cloning of amyloid precursor protein β-secretase from human brain
Nature . 1999 Dec 02 ; 402(6761) 537 | DOI : 10.1038/990114
- S. Sinha
- et al