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Peptides

ß-Secretase Inhibitor 1 - 1 mg

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  • Cat.Number : AS-23958
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ß-Secretase (BACE1) is a key enzyme involved in the production of Aß peptides found in extracellular amyloid plaques of Alzheimer’s disease (AD). The enzyme has been implicated as an excellent target for anti-amyloid therapy of AD. This statine-based substrate analog, beta-secretase inhibitor P10–P4’ statV, is used in the inhibition of beta-secretase activity from homogenized wild-type mouse cortices and from BACE-purified from human brain.

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References

Conformational analysis of peptides derived from the BRI gene

Spectroscopy . 2001 Jan 20 ; 15 129

  • V. Lelyveld
  • et al

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers

J Biol Chem, . 2015 Jul 01 ; 290(27) 16502 | DOI : https://doi.org/10.1074/jbc.M115.652263

  • A. Cantlon
  • et al

Purification and cloning of amyloid precursor protein β-secretase from human brain

Nature . 1999 Dec 02 ; 402(6761) 537 | DOI : 10.1038/990114

  • S. Sinha
  • et al