Peptides

490 MMP Substrate 16 (TNO211) - 1 mg

$274.00
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  • Cat.Number : AS-25350
  • Availability :
    In production

Quantity

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.

Specifications

Chemistry
Sequence one letter code
  • DABCYL-(γ-Abu)-PQGL-E(EDANS)AK-NH2
Sequence three letter code
  • DABCYL-(γ-Abu)-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2
CAS registry number
  • 193475-71-7
Molecular Formula
  • C63H88N16O14S
Molecular Mass/ Weight
  • 1325.6
Properties
Absorbance (nm)
  • 340
Emission (nm)
  • 490
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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References

Molecular imaging of MMP expression and therapeutic MMP inhibition

Acad Radiol . 1996 Jul 22 ; 9 Suppl 2 S314 | DOI : 10.1016/s1076-6332(03)80214-3.

  • C. Bremer
  • et al

Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media

FEBS Lett . 1996 Jul 22 ; 390(2) 221 | DOI : https://doi.org/10.1016/0014-5793(96)00665-5

  • B. Beekman
  • et al