490 MMP Substrate XVI (TNO211) - 1 mg
- Cat.Number : AS-25350
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Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.
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References
Molecular imaging of MMP expression and therapeutic MMP inhibition
Acad Radiol . 1996 Jul 22 ; 9 Suppl 2 S314 | DOI : 10.1016/s1076-6332(03)80214-3.
- C. Bremer
- et al
Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media
FEBS Lett . 1996 Jul 22 ; 390(2) 221 | DOI : https://doi.org/10.1016/0014-5793(96)00665-5
- B. Beekman
- et al