IMG-EN-AS-29945-1-01.jpg
Peptides

AKT/PKB/Rac-Protein Kinase Substrate [ARKRERTYSFGHHA], Biotinylated

$191.00
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  • Cat.Number : AS-29945-1
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    In production

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The native peptide ARKRERTYSFGHHA (29944-1) is a synthetic substrate for AKT/PKB/Rac-protein kinases. Phophorylation is at the Ser site (Km = 3.9 µM). It also competitively inhibits histone H2B phosphorylation (Ki = 12 µM) by AKT.

Specifications

Chemistry
Sequence one letter code
  • Biotin-ARKRERTYSFGHHA
Sequence three letter code
  • Biotin-Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala-OH
Molecular Formula
  • C84H128N30O22S
Molecular Mass/ Weight
  • 1942.3
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Pim kinase substrate identification and specificity.

J. Biochem. . 2007 Jan 18 ; 141(3) 353 | DOI : 10.1093/jb/mvm040

  • C. Peng

References

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Ann Rev Biochem . 1999 Jul 01 ; 68(1) 965 | DOI : https://doi.org/10.1146/annurev.biochem.68.1.965

  • TO. Chan
  • et al

Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB

JBC . 2000 Nov 01 ; 275(46) 36108 | DOI : https://doi.org/10.1074/jbc.M005497200

  • T. Obata
  • et al