IMG-EN-AS-60171-5-01.jpg
Peptides

Aminopeptidase N Ligand (CD13), NGR peptide - 5 mg

$599.00
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  • Cat.Number : AS-60171-5
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    In stock

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The NGR (Asn-Gly-Arg) peptide motif is an aminopeptidase N (CD13) ligand that targets angiogenic blood vessels. NGR-containing peptides have been proven useful for delivering cytotoxic drugs, proapoptotic peptides and tumor necrosis factor (TNF) to tumor vasculature.

Specifications

Chemistry
Sequence one letter code
  • CNGRCG (Disulfide bridge: 1-5)
Sequence three letter code
  • H-Cys-Asn-Gly-Arg-Cys-Gly-OH (Disulfide bridge: 1-5)
Molecular Formula
  • C20H36N10O8S2
Molecular Mass/ Weight
  • 606.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use

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References

Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells.

Cancer Res. . 2002 Feb 01 ; 62(3) 867 | DOI : PMID: 11830545

  • F. Curnis
  • et al

Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration.

J Clin Invest. . 2002 Aug 01 ; 110(4) 475 | DOI : 10.1172/JCI15223

  • F. Curnis