Peptides

Antennapedia Peptide, acid - 1 mg

$107.00
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  • Cat.Number : AS-61032
  • Availability :
    In production

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The Antennapedia homeodomain protein of Drosophila has the ability to penetrate biological membranes and the third helix of this protein, residues 43-58, known as penetratin (RQIKIWFQNRRMKWKK-amide) has the same translocating properties as the entire protein.
This is a 16 amino acid peptide corresponding to the region within the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization. The peptide has been shown to be able to translocate through the plasma membrane to the cytosol and nucleus of living cells, both at 37 °C and 4 °C.

Specifications

Chemistry
Sequence one letter code
  • RQIKIWFQNRRMKWKK
Sequence three letter code
  • Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
CAS registry number
  • 329306-46-9
Molecular Formula
  • C104H168N34O20S
Molecular Mass/ Weight
  • 2246.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Drosophila

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Citations

Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors.

Cancer Res . 2005 Sep 01 ; 65(17) 7840 | DOI : 10.1158/0008-5472.CAN-05-0662.

  • M. Jain

References

A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway.

Vaccine . 2001 Dec 08 ; 19(11) 1397 | DOI : https://doi.org/10.1016/S0264-410X(00)00373-X

  • GA. Pietersz
  • et al

Membrane interaction and cellular internalization of penetratin peptides.

Eur J Biochem . 2004 Feb 25 ; 27(16) 1187 | DOI : 10.1111/j.1432-1033.2004.04022.x

  • B. Christiaens
  • et al