IMG-EN-AS-64212-01.jpg
Peptides

Antennapedia Peptide, FAM-labeled - 1 mg

$311.00
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  • Cat.Number : AS-64212
  • Availability :
    In production

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The Antennapedia homeodomain protein of Drosophila has the ability to penetrate biological membranes and the third helix of this protein, residues 43-58, known as penetratin (RQIKIWFQNRRMKWKK-amide) has the same translocating properties as the entire protein.
This is a 16 amino acid peptide corresponding to the region within the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization. It is FAM-labeled with Abs/Em = 492/518 nm. The peptide has been shown to be able to translocate through the plasma membrane to the cytosol and nucleus of living cells, both at 37 °C and 4 °C.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-RQIKIWFQNRRMKWKK-NH2
Sequence three letter code
  • 5-FAM-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2
Molecular Formula
  • C125H179N35O25S1
Molecular Mass/ Weight
  • 2604.2
Properties
Absorbance (nm)
  • 492
Emission (nm)
  • 518
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Drosophila

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References

A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway

Vaccine . 2001 Dec 08 ; 19(11) 1397 | DOI : https://doi.org/10.1016/S0264-410X(00)00373-X

  • GA. Pietersz

Membrane interaction and cellular internalization of penetratin peptides

Eur J Biochem. . 2004 Feb 25 ; 271(6) 1187 | DOI : https://doi.org/10.1111/j.1432-1033.2004.04022.x

  • B. Christiaens
  • et al