Antennapedia Peptide, FAM-labeled - 1 mg
- Cat.Number : AS-64212
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The Antennapedia homeodomain protein of Drosophila has the ability to penetrate biological membranes and the third helix of this protein, residues 43-58, known as penetratin (RQIKIWFQNRRMKWKK-amide) has the same translocating properties as the entire protein.
This is a 16 amino acid peptide corresponding to the region within the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization. It is FAM-labeled with Abs/Em = 492/518 nm. The peptide has been shown to be able to translocate through the plasma membrane to the cytosol and nucleus of living cells, both at 37 °C and 4 °C.
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References
A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway
Vaccine . 2001 Dec 08 ; 19(11) 1397 | DOI : https://doi.org/10.1016/S0264-410X(00)00373-X
- GA. Pietersz
Membrane interaction and cellular internalization of penetratin peptides
Eur J Biochem. . 2004 Feb 25 ; 271(6) 1187 | DOI : https://doi.org/10.1111/j.1432-1033.2004.04022.x
- B. Christiaens
- et al